Title : Upregulation of CHOP-10 (gadd153) expression in the mouse blastocyst as a response to stress.

Pub. Date : 1999 Dec

PMID : 10542372






2 Functional Relationships(s)
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1 When mouse blastocysts were exposed to the alkylating agent MMS, the metabolic inhibitor sodium arsenite or an inhibitor of protein glycosylation tunicamycin, levels of the CHOP-10 mRNA were increased by two- to threefold relative to the mRNA for beta-actin. Tunicamycin DNA-damage inducible transcript 3 Mus musculus
2 The results suggest that there is a link between the extent of glycoprotein synthesis and the sensitivity of CHOP-10 to tunicamycin. Tunicamycin DNA-damage inducible transcript 3 Mus musculus