Title : Oxalate-induced changes in the viability and growth of human renal epithelial cells.

Pub. Date : 1999 Nov

PMID : 10541281






3 Functional Relationships(s)
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1 Oxalate-induced changes were also assessed in the expression of two genes: egr-1, a zinc-finger transcription factor, and osteopontin, a protein associated with tissue remodeling. Oxalates secreted phosphoprotein 1 Homo sapiens
2 This mitogenic effect offset cell loss at lower oxalate concentrations (88 microM) leading to a small but significant increase in cell number at 72 h. Treatment with oxalate also increased expression of egr-1 mRNA within 1 h, a response that was attenuated by MnTMPyP; oxalate treatment for 8 h also increased abundance of osteopontin mRNA. Oxalates secreted phosphoprotein 1 Homo sapiens
3 This mitogenic effect offset cell loss at lower oxalate concentrations (88 microM) leading to a small but significant increase in cell number at 72 h. Treatment with oxalate also increased expression of egr-1 mRNA within 1 h, a response that was attenuated by MnTMPyP; oxalate treatment for 8 h also increased abundance of osteopontin mRNA. Oxalates secreted phosphoprotein 1 Homo sapiens