Title : Risk factors for Ki-ras protooncogene mutation in sporadic colorectal adenomas.

Pub. Date : 1999 Oct 15

PMID : 10537295






4 Functional Relationships(s)
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1 A higher risk of Ki-ras mutations was associated with increasing age and a lower intake of total folate. Folic Acid KRAS proto-oncogene, GTPase Homo sapiens
2 Compared with individuals in the lower tertile of total folate, those in the upper tertile had an approximately 50% lower risk of having Ki-ras mutation-positive adenomas (OR = 0.52; 95% CI = 0.30-0.88; P for trend = 0.02). Folic Acid KRAS proto-oncogene, GTPase Homo sapiens
3 The results of these analyses suggest that the protective effect of folate in colon cancer observed in published studies may be mediated through folate"s effect on Ki-ras mutations. Folic Acid KRAS proto-oncogene, GTPase Homo sapiens
4 The results of these analyses suggest that the protective effect of folate in colon cancer observed in published studies may be mediated through folate"s effect on Ki-ras mutations. Folic Acid KRAS proto-oncogene, GTPase Homo sapiens