Title : Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists.

Pub. Date : 1999 Nov

PMID : 10531390






1 Functional Relationships(s)
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1 Three-dimensional models built on the basis of the predicted structure of rhodopsin showed that Tyr(308) of the beta(2)AR covered the binding pocket formed by TM2 and TM7 from the upper side, and Thr(117) of the beta(1)AR located in the middle of the binding pocket to provide a hydrogen bonding for the beta(1)-selective agonists. Threonine adrenoceptor beta 2 Homo sapiens