Title : Regulation of aquaporin-2 expression by the alpha(2)-adrenoceptor agonist clonidine in the rat.

Pub. Date : 1999 Nov

PMID : 10525117






4 Functional Relationships(s)
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1 Regulation of aquaporin-2 expression by the alpha(2)-adrenoceptor agonist clonidine in the rat. Clonidine aquaporin 2 Rattus norvegicus
2 The increase in free water clearance with clonidine administration was associated with a reduction in whole kidney AQP-2 mRNA levels (282+/-25 versus 216+/-11 A units, p<.05). Clonidine aquaporin 2 Rattus norvegicus
3 The rapid redistribution of AQP-2 and the reduction in AQP-2 mRNA following clonidine administration are consistent with the hypothesis that the alpha(2) adrenoceptor regulates water excretion at least in part by effects on AQP-2. Clonidine aquaporin 2 Rattus norvegicus
4 The rapid redistribution of AQP-2 and the reduction in AQP-2 mRNA following clonidine administration are consistent with the hypothesis that the alpha(2) adrenoceptor regulates water excretion at least in part by effects on AQP-2. Clonidine aquaporin 2 Rattus norvegicus