Title : Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages.

Pub. Date : 1999 Sep

PMID : 10510445






3 Functional Relationships(s)
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1 5 Finally, expression of iNOS protein induced by LPS plus IFN-gamma in RAVSMC and RAW 264.7 cells was suppressed by YS 49, in a concentration-dependent manner. Yttrium nitric oxide synthase 2, inducible Mus musculus
2 6 These data strongly suggest that YS 49 suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level. Yttrium nitric oxide synthase 2, inducible Mus musculus
3 YS 49 could therefore be beneficial in septic shock and other diseases associated with iNOS over-expression. Yttrium nitric oxide synthase 2, inducible Mus musculus