Title : Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone.

Pub. Date : 1999 Sep

PMID : 10510156






1 Functional Relationships(s)
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1 Sulphaphenazole caused limited inhibition (<30%) of both pathways in human liver microsomes and microsomes from cells transfected with CYP2C9 cDNA were able to mediate the metabolism of rosiglitazone, in particular the N-demethylation pathway, albeit at a much slower rate than CYP2C8. Sulfaphenazole cytochrome P450 family 2 subfamily C member 8 Homo sapiens