Title : Studies of the molecular mechanism of discrimination between cGMP and cAMP in the allosteric sites of the cGMP-binding cGMP-specific phosphodiesterase (PDE5).

Pub. Date : 1999 Oct 8

PMID : 10506154






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The regulatory domain of the cGMP-binding cGMP-specific 3":5"-cyclic nucleotide phosphodiesterase (PDE5) contains two homologous segments of amino acid sequence that encode allosteric cyclic nucleotide-binding sites, referred to as site a and site b, which are highly selective for cGMP over cAMP. Nucleotides, Cyclic phosphodiesterase 5A Homo sapiens
2 Using site-directed mutagenesis, a conserved residue, Asp-289, in site a of PDE5 has been identified as being important for cyclic nucleotide discrimination in this site. Nucleotides, Cyclic phosphodiesterase 5A Homo sapiens