Pub. Date : 1999 Aug
PMID : 10497893
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mutational analysis of Raf-1 cysteine rich domain: requirement for a cluster of basic aminoacids for interaction with phosphatidylserine. | Phosphatidylserines | Raf-1 proto-oncogene, serine/threonine kinase | Homo sapiens |
| 2 | In the present study, we have investigated the consequences of progressive deletions and point mutations within the cysteine-rich domain of Raf-1 on its ability to bind PS. | Phosphatidylserines | Raf-1 proto-oncogene, serine/threonine kinase | Homo sapiens |
| 3 | A reduced interaction with PS was observed in vitro for all deletion mutants of Raf-1 expressed either as full-length proteins or as fragments containing the isolated cysteine-rich domain. | Phosphatidylserines | Raf-1 proto-oncogene, serine/threonine kinase | Homo sapiens |
| 4 | Expression of Raf-1 in vivo, containing point mutations in the cysteine-rich domain resulted in a truncated polypeptide that lacked both the Ras and PS binding sites and could no longer translocate to the plasma membrane upon serum stimulation. | Phosphatidylserines | Raf-1 proto-oncogene, serine/threonine kinase | Homo sapiens |