Title : Intra-A chain disulphide bond forms first during insulin precursor folding.

Pub. Date : 1999 Oct 1

PMID : 10493922






8 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Intra-A chain disulphide bond forms first during insulin precursor folding. disulphide insulin Homo sapiens
2 The intra-A chain disulphide bond was found to form early in insulin precursor folding, whereas the corresponding disulphide bond in IGF-I formed late. disulphide insulin Homo sapiens
3 Time courses of oxidation of reduced insulin A chains, reduced A and B chains, and reduced proinsulins showed that the intra-A chain disulphide bond formed first during insulin precursor folding. disulphide insulin Homo sapiens
4 Time courses of oxidation of reduced insulin A chains, reduced A and B chains, and reduced proinsulins showed that the intra-A chain disulphide bond formed first during insulin precursor folding. disulphide insulin Homo sapiens
5 The time course of helix structure formation of insulin A chains also indicated that the intra-A chain disulphide bond formed first, and could stabilize partially folded A chain helix structure. disulphide insulin Homo sapiens
6 The rate of intra-A chain disulphide bond formation was almost the same as that for both helix structure formation and insulin molecule formation, indicating that the formation of the intra-A chain disulphide bond was the rate limiting step for the folding of insulin precursor. disulphide insulin Homo sapiens
7 The rate of intra-A chain disulphide bond formation was almost the same as that for both helix structure formation and insulin molecule formation, indicating that the formation of the intra-A chain disulphide bond was the rate limiting step for the folding of insulin precursor. disulphide insulin Homo sapiens
8 The rate of intra-A chain disulphide bond formation was almost the same as that for both helix structure formation and insulin molecule formation, indicating that the formation of the intra-A chain disulphide bond was the rate limiting step for the folding of insulin precursor. disulphide insulin Homo sapiens