Title : Preferential platination of an activated cellular promoter by cis-diamminedichloroplatinum.

Pub. Date : 1999 Sep 21

PMID : 10493812






2 Functional Relationships(s)
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1 Treatment of cells with 9-cis retinoic acid enhanced accessibility to cisplatin on the retinoic acid receptor beta gene promoter region, but not on the coding regions of that gene nor on the dihydrofolate reductase gene promoter or coding regions, where accessibilities to cisplatin remained 2-4 times lower than on the activated retinoic acid receptor beta gene promoter. Tretinoin retinoic acid receptor beta Homo sapiens
2 Treatment of cells with 9-cis retinoic acid enhanced accessibility to cisplatin on the retinoic acid receptor beta gene promoter region, but not on the coding regions of that gene nor on the dihydrofolate reductase gene promoter or coding regions, where accessibilities to cisplatin remained 2-4 times lower than on the activated retinoic acid receptor beta gene promoter. Tretinoin retinoic acid receptor beta Homo sapiens