Pub. Date : 1999 Sep 24
PMID : 10488090
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | tBHQ and SUL also activated MAPK kinase. | 2-tert-butylhydroquinone | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Inhibition of MAPK kinase with its inhibitor, PD98059, abolished ERK2 activation and impaired the induction of quinone reductase, a phase II detoxifying enzyme, and antioxidant response element (ARE)-linked reporter gene by tBHQ and SUL. | 2-tert-butylhydroquinone | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Overexpression of a dominant-negative mutant of ERK2 also attenuated tBHQ and SUL induction of ARE reporter gene activity. | 2-tert-butylhydroquinone | mitogen-activated protein kinase 1 | Homo sapiens |