Title : PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity.

Pub. Date : 1999 Aug 25

PMID : 10477832






1 Functional Relationships(s)
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1 These results suggest that PGHS-2 inhibitors DuP-697 and NS-398 possibly interact with PGHS-1 at a site different from the enzyme"s catalytic site, thus causing attenuation of PGHS-1 inhibition by aspirin and indomethacin without altering PGHS-1 basal activity or the ibuprofen-induced inhibition. Ibuprofen prostaglandin-endoperoxide synthase 1 Homo sapiens