Title : Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate.

Pub. Date : 1999 Oct 1

PMID : 10462699






4 Functional Relationships(s)
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1 Immunocomplex kinase experiments showed that EGCG inhibited the activities of cyclin-dependent kinase 2 (Cdk2) and 4 (Cdk4) in a dose-dependent manner in the cell-free system. epigallocatechin gallate cyclin dependent kinase 2 Homo sapiens
2 Immunocomplex kinase experiments showed that EGCG inhibited the activities of cyclin-dependent kinase 2 (Cdk2) and 4 (Cdk4) in a dose-dependent manner in the cell-free system. epigallocatechin gallate cyclin dependent kinase 2 Homo sapiens
3 As the cells were exposed to EGCG (30 microM) over 24 h a gradual loss of both Cdk2 and Cdk4 kinase activities occurred. epigallocatechin gallate cyclin dependent kinase 2 Homo sapiens
4 These results suggest that EGCG either exerts its growth-inhibitory effects through modulation of the activities of several key G1 regulatory proteins such as Cdk2 and Cdk4 or mediates the induction of Cdk inhibitor p21 and p27. epigallocatechin gallate cyclin dependent kinase 2 Homo sapiens