Title : Grapefruit juice has no effect on quinine pharmacokinetics.

Pub. Date : 1999 Jul

PMID : 10456490






1 Functional Relationships(s)
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1 OBJECTIVE: As quinine is mainly metabolised by human liver CYP3A4 and grapefruit juice inhibits CYP3A4, the effect of grapefruit juice on the pharmacokinetics of quinine following a single oral dose of 600 mg quinine sulphate was investigated. Quinine cytochrome P450 family 3 subfamily A member 4 Homo sapiens