Pub. Date : 1999 Sep 1
PMID : 10455016
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lysine mutagenesis identifies cationic charges of human CYP17 that interact with cytochrome b5 to promote male sex-hormone biosynthesis. | Lysine | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | That the defect could be essentially reversed by lysine mutagenesis has led to the conclusion that the cationic charges on all three residues (at the positions of Arg(347), Arg(358), Arg(449)) are vital for the functional interaction of CYP17 with cytochrome b(5) and that the loss of any one of these cationic charges is catastrophic. | Lysine | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |