Title : Strategies toward the design of novel and selective protein tyrosine kinase inhibitors.

Pub. Date : 1999 May-Jun

PMID : 10454197






1 Functional Relationships(s)
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1 Further successful application of this pharmacophore model led to the identification and optimization of phenylamino-pyrazolo[4,3-d]pyrimidines and substituted isoflavones and quinolones, other classes of potent, selective, and ATP competitive EGFR kinase inhibitors with IC50 values in the low nanomolar range. Isoflavones epidermal growth factor receptor Homo sapiens