Title : Thrombin inhibits active sodium-potassium transport in porcine lens.

Pub. Date : 1999 Aug

PMID : 10440258






4 Functional Relationships(s)
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1 Thrombin inhibits active sodium-potassium transport in porcine lens. Sodium coagulation factor II, thrombin Homo sapiens
2 In the present study, experiments were conducted to determine the influence of thrombin on active sodium-potassium transport in porcine lenses. Sodium coagulation factor II, thrombin Homo sapiens
3 The inhibitory effect of thrombin on ouabain-sensitive potassium (86Rb) uptake was suppressed in the presence of hirudin (an antagonist for thrombin receptors) but persisted in the presence of amphotericin B (a pseudo ionophore that effectively clamps plasma membrane sodium permeability at a high value). Sodium coagulation factor II, thrombin Homo sapiens
4 The functional significance of the thrombin-mediated change of lens active sodium-potassium transport is unclear since appreciable amounts of thrombin may only be presented to the lens during instances of blood-aqueous-barrier breakdown. Sodium coagulation factor II, thrombin Homo sapiens