Pub. Date : 1999 Jul 22
PMID : 10435640
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tamoxifen induces p21WAF1 and p27KIP1 expression in estrogen receptor-negative lung cancer cells. | Tamoxifen | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 2 | We next examined the effect of Tam on the expression of cyclin-dependent kinase inhibitors (CDKIs) and our results demonstrated that the expression of p21WAF1 and p27KIP1, but not p57KIP2, was strongly activated by Tam in these cells. | Tamoxifen | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 3 | We next examined the effect of Tam on the expression of cyclin-dependent kinase inhibitors (CDKIs) and our results demonstrated that the expression of p21WAF1 and p27KIP1, but not p57KIP2, was strongly activated by Tam in these cells. | Tamoxifen | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 4 | The amounts of p21WAF1 and p27KIP1 co-immunoprecipitated with cyclin E were obviously increased after Tam treatment and reduced activity of cyclin E-associated kinases and accumulation of hypo-phosphorylated retinoblastoma (Rb) protein were clearly detected in Tam-incubated cells. | Tamoxifen | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 5 | Considered together, these results suggest that Tam-induced growth inhibition in ER-negative lung cancer cells is associated with induction of p21WAF1 and p27KIP1. | Tamoxifen | cyclin dependent kinase inhibitor 1B | Homo sapiens |