Title : Tyramine produces interstitial adenosine-mediated activation of ecto-5'-nucleotidase in rat heart in vivo.

Pub. Date : 1999 Jun 11

PMID : 10422637






1 Functional Relationships(s)
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1 Tyramine (1 mM) increased the adenosine concentration measured in the presence of 100 microM AMP (i.e., the activity of ecto-5"-nucleotidase) by 65.8 +/- 19.9% (n = 6, P < 0.05), an increase which was inhibited by an antagonist of the alpha1-adrenoceptor (prazosin, 50 microM) or of protein kinase C (chelerythrine, 10 microM). Prazosin 5' nucleotidase, ecto Rattus norvegicus