Pub. Date : 1999 Jul 5
PMID : 10407170
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CREB mediates the cAMP-responsiveness of the tyrosine hydroxylase gene: use of an antisense RNA strategy to produce CREB-deficient PC12 cell lines. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 2 | cAMP initiates the PKA signaling cascade in rat pheochromocytoma PC12 cells, resulting in transcriptional activation of the tyrosine hydroxylase (TH) gene. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 3 | cAMP initiates the PKA signaling cascade in rat pheochromocytoma PC12 cells, resulting in transcriptional activation of the tyrosine hydroxylase (TH) gene. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 4 | This effect is mediated primarily through the cAMP responsive element (CRE), located at position -45 to -38 within the TH gene promoter. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 5 | Promoter analysis experiments demonstrated that cAMP-mediated inducibility of either TH gene proximal promoter activity or the activity of the TH CRE by itself fused upstream of a basal promoter was diminished in CREB-deficient cell lines. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 6 | Promoter analysis experiments demonstrated that cAMP-mediated inducibility of either TH gene proximal promoter activity or the activity of the TH CRE by itself fused upstream of a basal promoter was diminished in CREB-deficient cell lines. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 7 | Most significantly, the cAMP-inducibility of endogenous TH mRNA was completely blocked in the CREB-deficient cells, indicating that the response of the endogenous gene to cAMP was dependent on CREB. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 8 | Most significantly, the cAMP-inducibility of endogenous TH mRNA was completely blocked in the CREB-deficient cells, indicating that the response of the endogenous gene to cAMP was dependent on CREB. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |