Title : Immunosuppressant FK506 inhibits inducible nitric oxide synthase gene expression at a step of NF-kappaB activation in rat hepatocytes.

Pub. Date : 1999 Jun

PMID : 10406194






2 Functional Relationships(s)
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1 Studies were performed to determine whether the immunosuppressants FK506 and cyclosporin A directly influence gene expression of inducible nitric oxide synthase by interleukin 1beta in hepatocytes. Tacrolimus interleukin 1 beta Rattus norvegicus
2 FK506 markedly inhibited the nitric oxide formation, inducible nitric oxide synthase protein synthesis and inducible nitric oxide synthase mRNA expression induced by interleukin 1beta, but cyclosporin A had no effects. Tacrolimus interleukin 1 beta Rattus norvegicus