PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10406194-3 1999 Studies were performed to determine whether the immunosuppressants FK506 and cyclosporin A directly influence gene expression of inducible nitric oxide synthase by interleukin 1beta in hepatocytes. Tacrolimus 67-72 interleukin 1 beta Rattus norvegicus 164-181 10406194-8 1999 FK506 markedly inhibited the nitric oxide formation, inducible nitric oxide synthase protein synthesis and inducible nitric oxide synthase mRNA expression induced by interleukin 1beta, but cyclosporin A had no effects. Tacrolimus 0-5 interleukin 1 beta Rattus norvegicus 166-183