Pub. Date : 1999 Jun
PMID : 10404639
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Determination of mRNA, and protein levels of p53, MDM2 and protein kinase CK2 subunits in F9 cells after treatment with the apoptosis-inducing drugs cisplatin and carboplatin. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |
| 2 | Here, we explored the effects of the chemotherapeutic drugs cisplatin and carboplatin on the mRNA and protein levels of p53, MDM2 and CK2 in a murine teratocarcinoma cell line F9. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |
| 3 | Six hours after cisplatin and carboplatin treatment, the RNA level of p53 dropped by 59% +/- 9% and 86% +/- 8% respectively, whereas the observed level of p53 protein rose to 7 and 10 times over the untreated control, respectively. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |
| 4 | Six hours after cisplatin and carboplatin treatment, the RNA level of p53 dropped by 59% +/- 9% and 86% +/- 8% respectively, whereas the observed level of p53 protein rose to 7 and 10 times over the untreated control, respectively. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |
| 5 | More than 50% apoptotic cells were seen after 6 h. We conclude that cisplatin and its second generation drug carboplatin act similarly i.e. both drugs cause a concomitant decrease in p53 mRNA and an increase in p53 protein level. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |
| 6 | More than 50% apoptotic cells were seen after 6 h. We conclude that cisplatin and its second generation drug carboplatin act similarly i.e. both drugs cause a concomitant decrease in p53 mRNA and an increase in p53 protein level. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |