PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10404639-0 1999 Determination of mRNA, and protein levels of p53, MDM2 and protein kinase CK2 subunits in F9 cells after treatment with the apoptosis-inducing drugs cisplatin and carboplatin. Cisplatin 149-158 transformation related protein 53, pseudogene Mus musculus 45-48 10404639-3 1999 Here, we explored the effects of the chemotherapeutic drugs cisplatin and carboplatin on the mRNA and protein levels of p53, MDM2 and CK2 in a murine teratocarcinoma cell line F9. Cisplatin 60-69 transformation related protein 53, pseudogene Mus musculus 120-123 10404639-6 1999 Six hours after cisplatin and carboplatin treatment, the RNA level of p53 dropped by 59% +/- 9% and 86% +/- 8% respectively, whereas the observed level of p53 protein rose to 7 and 10 times over the untreated control, respectively. Cisplatin 16-25 transformation related protein 53, pseudogene Mus musculus 70-73 10404639-6 1999 Six hours after cisplatin and carboplatin treatment, the RNA level of p53 dropped by 59% +/- 9% and 86% +/- 8% respectively, whereas the observed level of p53 protein rose to 7 and 10 times over the untreated control, respectively. Cisplatin 16-25 transformation related protein 53, pseudogene Mus musculus 155-158 10404639-8 1999 More than 50% apoptotic cells were seen after 6 h. We conclude that cisplatin and its second generation drug carboplatin act similarly i.e. both drugs cause a concomitant decrease in p53 mRNA and an increase in p53 protein level. Cisplatin 68-77 transformation related protein 53, pseudogene Mus musculus 183-186 10404639-8 1999 More than 50% apoptotic cells were seen after 6 h. We conclude that cisplatin and its second generation drug carboplatin act similarly i.e. both drugs cause a concomitant decrease in p53 mRNA and an increase in p53 protein level. Cisplatin 68-77 transformation related protein 53, pseudogene Mus musculus 211-214