Title : Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1 beta and TNF-alpha.

Pub. Date : 1999 Jul 15

PMID : 10395693






1 Functional Relationships(s)
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1 Macrophages exposed to LPS showed a rapid and sustained expression of COX-2 mRNA and protein for up to 48 h, whereas PGE2 production was notably enhanced only after 12 h. LPS increased COX-2 gene transcription and activation of the transcription factor NF-kappa B in a transient manner. Dinoprostone nuclear factor kappa B subunit 1 Homo sapiens