Title : Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells.

Pub. Date : 1999 Jul 9

PMID : 10391929






3 Functional Relationships(s)
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1 We have shown previously that the JAK2 tyrosine kinase and the Src family p59 Fyn tyrosine kinase are required for Ang II-induced STAT1 tyrosine phosphorylation in VSMCs. Tyrosine angiotensinogen Homo sapiens
2 In the present study, using specific enzyme inhibitors and antisense oligonucleotides, we show that Ang II-induced tyrosine phosphorylation and nuclear translocation of STAT3 in VSMCs is mediated by p60 c-Src, whereas tyrosine dephosphorylation is mediated by calcineurin. Tyrosine angiotensinogen Homo sapiens
3 In the present study, using specific enzyme inhibitors and antisense oligonucleotides, we show that Ang II-induced tyrosine phosphorylation and nuclear translocation of STAT3 in VSMCs is mediated by p60 c-Src, whereas tyrosine dephosphorylation is mediated by calcineurin. Tyrosine angiotensinogen Homo sapiens