Title : K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.

Pub. Date : 1999 Jul 1

PMID : 10391558






2 Functional Relationships(s)
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1 p53 mutations were found in 4 of 16 GCCs (25%) and 8 of 18 TCs (44%). 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide tumor protein p53 Homo sapiens
2 CONCLUSIONS: p53 mutations appear to play a role in the pathogenesis of some GCCs and in approximately 50% of TCs of the appendix, whereas mutations in the K-ras oncogene do not appear to be important in the development of these tumors. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide tumor protein p53 Homo sapiens