Title : Cytosine methylation transforms an E2F site in the retinoblastoma gene promoter into a binding site for the general repressor methylcytosine-binding protein 2 (MeCP2).

Pub. Date : 1999 Jul 15

PMID : 10390525






1 Functional Relationships(s)
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1 However, aberrant methylation of CpG dinucleotides within the Rb-1 promoter has been depicted in certain tumors, which determines transcriptional inactivity of the gene and absence of the pRb retinoblastoma protein. cytidylyl-3'-5'-guanosine RB transcriptional corepressor 1 Homo sapiens