Title : [Endonuclease activity of recombinant pancreatic nuclease (A-K7H)].

Pub. Date : 1999

PMID : 10386039






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this work is analysed endonuclease activity of recombinant pancreatic RNase A (K7H), that in position seven instead of a lysine there is a histidine, amino acid residue that participates in main catalytic site p1. Histidine ribonuclease A family member 1, pancreatic Homo sapiens
2 Results of this investigation have shown that substitution of lysine by histidine in position seven of RNase A has produced total deletion of p2 subsite, and K7H has lost endonuclease activity, and has become exonuclease. Histidine ribonuclease A family member 1, pancreatic Homo sapiens