Title : Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis.

Pub. Date : 1999 Jul

PMID : 10385685






1 Functional Relationships(s)
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1 Chemical mutagenesis with N-methyl-N-nitrosourea was employed to study the pattern of mutations in the reduced folate carrier (RFC1) that results in transport-related methotrexate resistance and to identify amino acid residues that are critical to carrier structure and/or function. Methotrexate replication factor C (activator 1) 1 Mus musculus