Title : CD44, a cell surface chondroitin sulfate proteoglycan, mediates binding of interferon-gamma and some of its biological effects on human vascular smooth muscle cells.

Pub. Date : 1999 Jul 2

PMID : 10383394






3 Functional Relationships(s)
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1 We found that treatment of HASMC with chondroitinase ABC, an enzyme that degrades chondroitin sulfate GAG, reduced IFN-gamma binding by more than 50%. Glycosaminoglycans interferon gamma Homo sapiens
2 The interaction of IFN-gamma with chondroitin sulfate GAG was confirmed by affinity chromatography of isolated cell-associated 35S-, 3H-labeled PG on a column with immobilized IFN-gamma. Glycosaminoglycans interferon gamma Homo sapiens
3 The interaction of IFN-gamma with chondroitin sulfate GAG was confirmed by affinity chromatography of isolated cell-associated 35S-, 3H-labeled PG on a column with immobilized IFN-gamma. Glycosaminoglycans interferon gamma Homo sapiens