Title : Differentiation of U937 cells enables a phospholipase D-dependent pathway of cytosolic phospholipase A2 activation.

Pub. Date : 1999 Jun 24

PMID : 10381372






2 Functional Relationships(s)
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Protein Name
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1 Ethanol acts as an alternate substrate in place of water for PLD producing phosphatidylethanol (PEt) instead of phosphatidic acid. Phosphatidic Acids glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 Further evidence for the involvement of PLD in the regulation of cPLA2 came from the observation that the stimulated production of diacylglycerol (for which phosphatidic acid is a major source) was greatly diminished in undifferentiated cells as compared to differentiated cells. Phosphatidic Acids glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens