Title : Insulin-induced desensitization of extracellular signal-regulated kinase activation results from an inhibition of Raf activity independent of Ras activation and dissociation of the Grb2-SOS complex.

Pub. Date : 1999 Jun 25

PMID : 10373477






1 Functional Relationships(s)
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1 Although treatment with the phorbol myristate acetate resulted in ERK activation and complete dissociation of the Grb2-SOS complex, there was no effect on subsequent insulin-stimulated Ras activation. Tetradecanoylphorbol Acetate growth factor receptor bound protein 2 Homo sapiens