Title : Role of regulatory exosite I in binding of thrombin to human factor V, factor Va, factor Va subunits, and activation fragments.

Pub. Date : 1999 Jun 25

PMID : 10373475






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Thrombin exosite interactions with human factor V and its activation products were quantitatively characterized in equilibrium binding studies based on fluorescence changes of thrombin covalently labeled with 2-anilinonaphthalene-6-sulfonic acid (ANS) linked to the catalytic site histidine residue by Nalpha-[(acetylthio)acetyl]-D-Phe-Pro-Arg-CH2Cl ([ANS]FPR-thrombin). Histidine coagulation factor II, thrombin Homo sapiens