Pub. Date : 1999 Jun
PMID : 10362723
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha-induced oxidant stress. | Silicon Dioxide | tumor necrosis factor | Mus musculus |
| 2 | We hypothesize that non-oxidant-mediated silica-cell interactions lead to the upregulation of tumor necrosis factor-alpha (TNF-alpha), whereby TNF-alpha-induced generation of reactive oxygen species (ROS) leads to the activation of the monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-2 genes. | Silicon Dioxide | tumor necrosis factor | Mus musculus |
| 3 | We hypothesize that non-oxidant-mediated silica-cell interactions lead to the upregulation of tumor necrosis factor-alpha (TNF-alpha), whereby TNF-alpha-induced generation of reactive oxygen species (ROS) leads to the activation of the monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-2 genes. | Silicon Dioxide | tumor necrosis factor | Mus musculus |
| 4 | We hypothesize that non-oxidant-mediated silica-cell interactions lead to the upregulation of tumor necrosis factor-alpha (TNF-alpha), whereby TNF-alpha-induced generation of reactive oxygen species (ROS) leads to the activation of the monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-2 genes. | Silicon Dioxide | tumor necrosis factor | Mus musculus |
| 5 | This ROS production could be inhibited with extracellular GSH treatment, and in the case of cristobalite-induced ROS, inhibition was also achieved with an anti-TNF-alpha antibody. | Silicon Dioxide | tumor necrosis factor | Mus musculus |
| 6 | The results support the hypothesis that TNF-alpha mediates cristobalite-induced MCP-1 and MIP-2 expression through the generation of ROS. | Silicon Dioxide | tumor necrosis factor | Mus musculus |