Title : A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose.

Pub. Date : 1999 Jun

PMID : 10361302






4 Functional Relationships(s)
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1 A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Cyclic AMP Gpr1p Saccharomyces cerevisiae S288C
2 We show that the G-protein coupled receptor (GPCR) Gpr1 interacts with Gpa2 and is required for stimulation of cAMP synthesis by glucose. Cyclic AMP Gpr1p Saccharomyces cerevisiae S288C
3 In addition, we isolated a mutant allele of GPR1, named fil2, in a screen for mutants deficient in glucose-induced loss of heat resistance, which is consistent with its lack of glucose-induced cAMP activation. Cyclic AMP Gpr1p Saccharomyces cerevisiae S288C
4 Apparently, Gpr1 together with Gpa2 constitute a glucose-sensing system for activation of the cAMP pathway. Cyclic AMP Gpr1p Saccharomyces cerevisiae S288C