Pub. Date : 1999 Jun 15
PMID : 10361139
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. | Iron | solute carrier family 11 member 2 | Homo sapiens |
| 2 | Genetic studies in animal models of microcytic anemia and biochemical studies of transport have implicated the Nramp2 gene in iron transport. | Iron | solute carrier family 11 member 2 | Homo sapiens |
| 3 | Nramp2 generates two alternatively spliced mRNAs that differ at their 3" untranslated region by the presence or absence of an iron-response element (IRE) and that encode two proteins with distinct carboxy termini. | Iron | solute carrier family 11 member 2 | Homo sapiens |
| 4 | Dietary iron starvation results in a dramatic upregulation of the Nramp2 isoform I in the proximal portion of the duodenum only, whereas expression in the rest of the small intestine and in kidney remains largely unchanged in response to the lack of dietary iron. | Iron | solute carrier family 11 member 2 | Homo sapiens |
| 5 | In proximal duodenum, immunostaining studies of tissue sections show that Nramp2 protein expression is abundant under iron deplete condition and limited to the villi and is absent in the crypts. | Iron | solute carrier family 11 member 2 | Homo sapiens |
| 6 | These results strongly suggest that Nramp2 is indeed responsible for transferrin-independent iron uptake in the duodenum. | Iron | solute carrier family 11 member 2 | Homo sapiens |