PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10361139-0 1999 Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Iron 52-56 solute carrier family 11 member 2 Homo sapiens 45-51 10361139-1 1999 Genetic studies in animal models of microcytic anemia and biochemical studies of transport have implicated the Nramp2 gene in iron transport. Iron 126-130 solute carrier family 11 member 2 Homo sapiens 111-117 10361139-2 1999 Nramp2 generates two alternatively spliced mRNAs that differ at their 3" untranslated region by the presence or absence of an iron-response element (IRE) and that encode two proteins with distinct carboxy termini. Iron 126-130 solute carrier family 11 member 2 Homo sapiens 0-6 10361139-6 1999 Dietary iron starvation results in a dramatic upregulation of the Nramp2 isoform I in the proximal portion of the duodenum only, whereas expression in the rest of the small intestine and in kidney remains largely unchanged in response to the lack of dietary iron. Iron 8-12 solute carrier family 11 member 2 Homo sapiens 66-72 10361139-7 1999 In proximal duodenum, immunostaining studies of tissue sections show that Nramp2 protein expression is abundant under iron deplete condition and limited to the villi and is absent in the crypts. Iron 118-122 solute carrier family 11 member 2 Homo sapiens 74-80 10361139-10 1999 These results strongly suggest that Nramp2 is indeed responsible for transferrin-independent iron uptake in the duodenum. Iron 93-97 solute carrier family 11 member 2 Homo sapiens 36-42