Title : 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor.

Pub. Date : 1999 Jun 3

PMID : 10354406






1 Functional Relationships(s)
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1 Evaluation of the O-methyl ether derivative of 4 suggested that the 3-hydroxymethyl substituent might be involved in a hydrogen-bond donor-type of interaction at a sterically compact region in the PNMT active site. o-methyl ether phenylethanolamine N-methyltransferase Homo sapiens