Pub. Date : 1999 Feb 1
PMID : 10348660
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival. | Ceramides | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | Overexpression of either aPKC isoform, PKC zeta or iota, resulted in enhanced survival of PC12 cells at high doses of ceramide and in ceramide-stimulated Jun N-terminal kinase (JNK), without any apparent effect on mitogen-activated kinase. | Ceramides | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | Overexpression of either aPKC isoform, PKC zeta or iota, resulted in enhanced survival of PC12 cells at high doses of ceramide and in ceramide-stimulated Jun N-terminal kinase (JNK), without any apparent effect on mitogen-activated kinase. | Ceramides | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 4 | These findings support a role for ceramide-induced PKC zeta activity in the control of cell survival signaling via a pathway that also activates JNK kinase. | Ceramides | mitogen-activated protein kinase 8 | Rattus norvegicus |