Pub. Date : 1999 Jun
PMID : 10347249
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Consistent with these findings, reconstituted SUR2A/KIR6.2 and SUR2B/KIR6.2 channels revealed similar sensitivities for glibenclamide and tolbutamide. | Glyburide | potassium inwardly-rectifying channel, subfamily J, member 11 | Rattus norvegicus |
| 2 | Consistent with these findings, reconstituted SUR2A/KIR6.2 and SUR2B/KIR6.2 channels revealed similar sensitivities for glibenclamide and tolbutamide. | Glyburide | potassium inwardly-rectifying channel, subfamily J, member 11 | Rattus norvegicus |
| 3 | Potencies of glibenclamide, glipizide, tolbutamide, and meglitinide to inhibit activity of SUR1/KIR6.2 and SUR2B/KIR6.2 channels were 3- to 6-fold higher than binding affinities of these drugs with concentration-inhibition relations being significantly steeper (Hill coefficients 1.23-1.32) than binding curves (Hill coefficients 0.93-1.06). | Glyburide | potassium inwardly-rectifying channel, subfamily J, member 11 | Rattus norvegicus |
| 4 | Potencies of glibenclamide, glipizide, tolbutamide, and meglitinide to inhibit activity of SUR1/KIR6.2 and SUR2B/KIR6.2 channels were 3- to 6-fold higher than binding affinities of these drugs with concentration-inhibition relations being significantly steeper (Hill coefficients 1.23-1.32) than binding curves (Hill coefficients 0.93-1.06). | Glyburide | potassium inwardly-rectifying channel, subfamily J, member 11 | Rattus norvegicus |