Pub. Date : 1999 May 21
PMID : 10329715
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We report here that HP1 is phosphorylated by casein kinase II in vivo at three serine residues located at the N and C termini of the protein. | Serine | Suppressor of variegation 205 | Drosophila melanogaster |
2 | Alanine substitution mutations in the casein kinase II target phosphorylation sites dramatically reduce the heterochromatin binding activity of HP1, whereas glutamate substitution mutations, which mimic the charge contributions of phosphorylated serine, have apparently wild-type binding activity. | Serine | Suppressor of variegation 205 | Drosophila melanogaster |