Title : Phosphorylation of heterochromatin protein 1 by casein kinase II is required for efficient heterochromatin binding in Drosophila.

Pub. Date : 1999 May 21

PMID : 10329715






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We report here that HP1 is phosphorylated by casein kinase II in vivo at three serine residues located at the N and C termini of the protein. Serine Suppressor of variegation 205 Drosophila melanogaster
2 Alanine substitution mutations in the casein kinase II target phosphorylation sites dramatically reduce the heterochromatin binding activity of HP1, whereas glutamate substitution mutations, which mimic the charge contributions of phosphorylated serine, have apparently wild-type binding activity. Serine Suppressor of variegation 205 Drosophila melanogaster