Pub. Date : 1999 May 21
PMID : 10329651
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Requirement of Erk, but not JNK, for arsenite-induced cell transformation. | arsenite | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Interestingly, arsenite induces Erk phosphorylation and increased Erk activity at doses ranging from 0.8 to 200 microM, while higher doses (more than 50 microM) are required for activation of JNK. | arsenite | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Interestingly, arsenite induces Erk phosphorylation and increased Erk activity at doses ranging from 0.8 to 200 microM, while higher doses (more than 50 microM) are required for activation of JNK. | arsenite | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Arsenite-induced Erk activation was markedly inhibited by introduction of dominant negative Erk2 into cells, while expression of dominant negative Erk2 did not show inhibition of JNK and MEK1/2. | arsenite | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Arsenite-induced Erk activation was markedly inhibited by introduction of dominant negative Erk2 into cells, while expression of dominant negative Erk2 did not show inhibition of JNK and MEK1/2. | arsenite | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | Furthermore, arsenite-induced cell transformation was blocked in cells expressing the dominant negative Erk2. | arsenite | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | Our results not only show that arsenite induces Erk activation, but also for the first time demonstrates that activation of Erk, but not JNK, by arsenite is required for its effects on cell transformation. | arsenite | mitogen-activated protein kinase 1 | Homo sapiens |
| 8 | Our results not only show that arsenite induces Erk activation, but also for the first time demonstrates that activation of Erk, but not JNK, by arsenite is required for its effects on cell transformation. | arsenite | mitogen-activated protein kinase 1 | Homo sapiens |
| 9 | Our results not only show that arsenite induces Erk activation, but also for the first time demonstrates that activation of Erk, but not JNK, by arsenite is required for its effects on cell transformation. | arsenite | mitogen-activated protein kinase 1 | Homo sapiens |