Pub. Date : 1999 Apr
PMID : 10328570
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The co-administration of sulfamethazine, which is known to be metabolized by a male-specific cytochrome P450 (CYP) isoform (CYP2C11), significantly decreased the CLp of acetohexamide in male Wistar-IM rats. | Acetohexamide | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 2 | Based on these results, it is reasonable to assume that the sex-dependent pharmacokinetics of acetohexamide observed in Wistar-IM rats is associated with the male-specific hydroxylation catalyzed by CYP2C11. | Acetohexamide | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |