Pub. Date : 1999 May 1
PMID : 10326760
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evidence that heparin but not hirudin reduces PAI-1 expression in cultured human endothelial cells. | Heparin | serpin family E member 1 | Homo sapiens |
| 2 | We have analyzed the effect of unfractionated heparin (UFH) and hirudin on PAI-1 gene expression in human umbilical vein endothelial cells (HUVEC). | Heparin | serpin family E member 1 | Homo sapiens |
| 3 | The addition of UFH (10 or 100 IU/ml) to endotoxin-stimulated HUVEC also reduced the increased PAI-1 mRNA and antigen secretion (45%), whereas no effect could be observed with hirudin. | Heparin | serpin family E member 1 | Homo sapiens |
| 4 | Our results suggest that UFH, but not hirudin, by reducing the endothelial expression of PAI-1 might have a profibrinolytic effect. | Heparin | serpin family E member 1 | Homo sapiens |