Title : Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase.

Pub. Date : 1999 May 15

PMID : 10233893






2 Functional Relationships(s)
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1 In addition, HA1077 and Y-27632 inhibited 20-kD MLC phosphorylation at Ser19 and ATP secretion of platelets stimulated with STA2, thrombin (0.05 U/mL), and simultaneous addition of serotonin and epinephrine, whereas these compounds did not affect MLC phosphorylation or ATP secretion when platelets were stimulated with more than 0.1 U/mL thrombin. Y 27632 coagulation factor II, thrombin Homo sapiens
2 In addition, HA1077 and Y-27632 inhibited 20-kD MLC phosphorylation at Ser19 and ATP secretion of platelets stimulated with STA2, thrombin (0.05 U/mL), and simultaneous addition of serotonin and epinephrine, whereas these compounds did not affect MLC phosphorylation or ATP secretion when platelets were stimulated with more than 0.1 U/mL thrombin. Y 27632 coagulation factor II, thrombin Homo sapiens