Title : Effects of epidermal growth factor on MDA-MB-468 breast cancer cells: alterations in polyamine biosynthesis and the expression of p21/CIP1/WAF1.

Pub. Date : 1999 Jun

PMID : 10228944






4 Functional Relationships(s)
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1 EGF treatment also caused a 30 to 50% decrease in cellular putrescine at all time points tested (12 to 48 h). Putrescine epidermal growth factor Homo sapiens
2 EGF-induced inhibition of DNA synthesis was also partially reversed by the addition of putrescine or spermidine, but not by spermine. Putrescine epidermal growth factor Homo sapiens
3 However, EGF had no significant effect on the expression of cyclin D1 or cyclin E. Furthermore, putrescine reversal of EGF effects was associated with the down-regulation of EGF-induced p21. Putrescine epidermal growth factor Homo sapiens
4 However, EGF had no significant effect on the expression of cyclin D1 or cyclin E. Furthermore, putrescine reversal of EGF effects was associated with the down-regulation of EGF-induced p21. Putrescine epidermal growth factor Homo sapiens