Title : Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation.

Pub. Date : 1999 May 7

PMID : 10224109






1 Functional Relationships(s)
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1 PG490 also inhibits PMA-stimulated activation of a chimeric transcription factor in which the C-terminal TA1 transactivation domain of NF-kappaB p65 is fused to the DNA binding domain of GAL4. triptolide RELA proto-oncogene, NF-kB subunit Homo sapiens