Title : Substitution studies of the second divalent metal cation requirement of protein tyrosine kinase CSK.

Pub. Date : 1999 Apr 27

PMID : 10220355






2 Functional Relationships(s)
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1 In this paper, we report that several divalent metal cations, such as Mn2+, Co2+, Ni2+, and Zn2+ bind to the second Mg2+-binding site of Csk with up to 13200-fold higher affinity than Mg2+. Cobalt(2+) C-terminal Src kinase Homo sapiens
2 Co2+ and Ni2+ supports reduced levels of Csk activity compared to Mg2+. Cobalt(2+) C-terminal Src kinase Homo sapiens